With Liverpool’s title charge already stuttering as a result of two draws from their opening two games, Jurgen Klopp could have done without any further injury blows.
But that is exactly what the German received during a tumultuous week which he described after Monday’s meeting with Crystal Palace was “like we had a witch in the building”.
Joel Matip and Roberto Firmino both missed that game after joining a lengthy list of absentees in the build-up.
The Sporting News is on hand to bring you the news on whether that pair are likely to return and the rest of the Reds’ team news ahead of a mouthwatering trip to face Manchester United at Old Trafford.
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Here’s how Liverpool’s XI could look, in a 4-3-3 formation: Alisson (GK) — Alexander-Arnold, Gomez, Van Dijk, Robertson — Elliott, Fabinho, Henderson — Salah, Firmino, Diaz
The good news for Klopp is that Firmino is expected to return to fitness in time to fill the vacancy created by Darwin Nunez’s suspension as a result of his red card against Crystal Palace.
However, Joel Matip is facing up to two weeks on the sidelines, and joins fellow defenders Ibrahima Konate and Calvin Ramsay in the treatment room. 
Joe Gomez should at least be fit to replace Nat Phillips at centre-half having started from the bench against Palace as a precaution.
But a number of long-term absentees will remain out, including midfielders Thiago Alcantara, Curtis Jones and Alex Oxlade-Chamberlain.
Meanwhile, Klopp’s attacking options will be thinned by the continued absence of Diogo Jota, and back-up goalkeeper Caomhin Kelleher remains unlikely to return.
Liverpool claimed the biggest ever away victory in clashes between the two great rivals during last season’s visit to Old Trafford, running out 5-0 winners.
Mohamed Salah bagged a hat-trick as Naby Keita and Diogo Jota also got on the scoresheet as Jurgen Klopp’s men ran riot in Manchester.
The Reds have won on their last two visits to M16 and have in fact avoided defeat there in the league since March 2018.